Tlag1^AKR/J
QTL Variant Detail

Summary

• QTL variant: Tlag1^AKR/J
• Name: T lymphoma attenuation gene 1; AKR/J
• MGI ID: MGI:3581261
• QTL: Tlag1 Location: Chr7:87073979-87142720 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL

Notes

Tlag1 and Tlag2 appear to interact. Animals homozygous for AKR/J-derived alleles at Tlag1 and heterozygous for AKR/J- and C57L/J-derived alleles at Tlag2 exhibit the greatest susceptibility to MNU-induced lymphomas.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:12885

149 (AKR/J x C57L/J)F2 mice were tested for MNU induced lymphoma tumor incidence (gene Tlag1). An association between Tlag1 and the albino locus was observed in which 50% (20/40) of c/c mice developed tumors whereas only 28% (31/109) of the nonalbino (C/C or C/c) mice did so. In 135 F2 mice there was also a significant association between Hbb and tumor incidence (19/41) over Hbb^d/s or Hbb^{s/ (26/94). There was also a significant association between Hbb and Tyr with Tlag1}

J:10061

AKR/J mice are susceptible to MNU inducrd thymic lymphoma. The authors indicate that susceptibility is controlled by several genes. In (AKR/J x C57L/J)F2 mice one gene (Tlag1) was shown associated with the albino locus, since 6/6 albinos had tumors, and only 2/27 nonalbinos had tumors. The association of tumor incidence with the albino locus suggests tight linkage of Tlag1 and Tyr^c on mouse Chromosome 7. X² = 17.8 1 df p <.0001.

References

• Original: J:10061 Angel JM, et al., Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. J Natl Cancer Inst. 1989 Nov 1;81(21):1652-5
• All: 2 reference(s)