Ril1^A/J
QTL Variant Detail

Summary

• QTL variant: Ril1^A/J
• Name: radiation-induced leukemia sensitivity 1; A/J
• MGI ID: MGI:3581270
• QTL: Ril1 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to radiation-induced leukemia compared to C57BL/10ScSn. (J:6610)
• Inheritance: Codominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6610

QTLs associated with susceptibility to radiation-induced leukemia were mapped using a population of (A/J x C57BL/10ScSn)F2 intercross animals. Parental strain C57BL/10ScSn is susceptible to radiation-induced leukemia compared to parental strain A/J. (A/Jx C57BL/10ScSn)F1 hybrids exhibit intermediate susceptibility. C57BL/10ScSn exhibits shorter latency and higher mortality than A/J. (A/J x C57BL/10ScSn)F1 hybrids exhibit longer latency similar to parental A/J but have high mortality similar to C57BL/10ScSn. Female animals appear to be more susceptible to leukemia induction but the difference was not found to be statistically significant.

A major locus for resistance to radiation-induced leukemia mapped to mouse Chromosome 2 near Ly11 (69 cM). This locusis named Ril1 (radiation-induced leukemia sensitivity 1). A/J-derived alleles at Ril1 confer resistance to radiation-induced leukemia with codominant inheritance. The Ril1 locus is thought to be proximal to Ly11.

A locus on mouse Chromosome 4 shows linkage to radiation-induced leukemia susceptibility near Cxv2 (62 cM). This locus is named Ril3 (radiation-induced leukemia sensitivity 2). Ril3 is estimated to be 1-3 cM proximal of Cxv2. F2 animals homozygous or heterozygous for C57BL/10ScSn-derived alleles at Ril3 exhibit increased survival after radiation exposure compared to animals homozygous for A/J-derived alleles at Ril3. Cxv2 is considered a likely candidate gene for Ril3 as Cxv2 expression is greater in susceptible strain A/J compared to resistantstrain C57BL/10ScSn.

A C57BL/10ScSn-derived resistance locus mapped to mouse Chromosome 1 near Pep3 (71 cM). This locus is named Ril2 (radiation-induced leukemia sensitivity 3). C57BL/10ScSn-derived alleles at Ril2 (heterozygous or homozygous) confer increased survival after radiation exposure. Bxv1 (92.3 cM) maps near Ril2 and may be a possible candidate gene.

References

• Original: J:6610 Meruelo D, et al., Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. J Exp Med. 1981 Oct 1;154(4):1201-11
• All: 1 reference(s)