About   Help   FAQ
Ril3C57BL/10ScSn
QTL Variant Detail
Summary
QTL variant: Ril3C57BL/10ScSn
Name: radiation-induced leukemia sensitivity 3; C57BL/10ScSn
MGI ID: MGI:3581275
QTL: Ril3  Location: unknown  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/10ScSn
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to radiation-induced leukemia compared to A/J. (J:6610)
Inheritance:    Not Specified
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6610

QTL associated with susceptibility to radiation-induced leukemia were mapped using a population of (A/J x C57BL/10ScSn)F2 intercross animals. Parental strain C57BL/10ScSn is susceptible to radiation-induced leukemia compared to parental strain A/J. (A/J x C57BL/10ScSn)F1 hybrids exhibit intermediate susceptibility. C57BL/10ScSn exhibits shorter latency and higher mortality than A/J. (A/J x C57BL/10ScSn)F1 hybrids exhibit longer latency similar to parental A/J but have high mortality similar to C57BL/10ScSn. Female animals appear to be more susceptible to leukemia induction but the difference was not found to be statistically significant.

A major locus for resistance to radiation-induced leukemia mapped to mouse Chromosome 2 near Ly11 (69 cM). This locusis named Ril1 (radiation-induced leukemia sensitivity 1). A/J-derived alleles at Ril1 confer resistance to radiation-induced leukemia with codominant inheritance. The Ril1 locus is thought to be proximal to Ly11.

A locus on mouse Chromosome 4 shows linkage to radiation-induced leukemia susceptibility near Cxv2 (62 cM). This locus is named Ril3 (radiation-induced leukemia sensitivity 2). Ril3 is estimated to be 1-3 cM proximal of Cxv2. F2 animals homozygous or heterozygous for C57BL/10ScSn-derived alleles at Ril3 exhibit increased survival after radiation exposure compared to animals homozygous for A/J-derived alleles at Ril3. Cxv2 is considered a likely candidate gene for Ril3 as Cxv2 expression is greater in susceptible strain A/J compared to resistantstrain C57BL/10ScSn.

A C57BL/10ScSn-derived resistance locus mapped to mouse Chromosome 1 near Pep3 (71 cM). This locus is named Ril2 (radiation-induced leukemia sensitivity 3). C57BL/10ScSn-derived alleles at Ril2 (heterozygous or homozygous) confer increased survival after radiation exposure. Bxv1 (92.3 cM) maps near Ril2 and may be a possible candidate gene.

References
Original:  J:6610 Meruelo D, et al., Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease. J Exp Med. 1981 Oct 1;154(4):1201-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory