Fntb^tm1.1Bbd
Targeted Allele Detail

Summary

• Symbol: Fntb^tm1.1Bbd
• Name: farnesyltransferase, CAAX box, beta; targeted mutation 1.1, Mariano Barbacid
• MGI ID: MGI:3581448
• Synonyms: FT^-
• Gene: Fntb Location: Chr12:76884014-76968188 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Fntb^tm1.1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98944
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre expression mediated the excision of the exon 3 in Fntb^tm1Bbd. The predominant transcript produced by the mutant allele does not contain a frameshift but rather encodes a protein with a short in-frame deletion. (J:98944, J:149075)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fntb Mutation: 208 strains or lines available

References

• Original: J:98944 Mijimolle N, et al., Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 2005 Apr;7(4):313-24
• All: 2 reference(s)