Cycs^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Cycs^tm1Mak
• Name: cytochrome c, somatic; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3581449
• Synonyms: KA
• Gene: Cycs Location: Chr6:50539543-50543518 bp, - strand Genetic Position: Chr6, 24.32 cM
• Alliance: Cycs^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: An AAA to GCA mutation in exon 3 at nt 216, causing an K72A substitution was knocked in to the locus. A cassette containing a loxP-flanked ACN cassette containing Cre-recombinase under the control of the testes-specific promoter and a neo cassette was inserted downstream of the polyA signal. Excision of the cre-neo cassette occurred upon passage through the male germ line. (J:98949)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cycs Mutation: 9 strains or lines available

References

• Original: J:98949 Hao Z, et al., Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell. 2005 May 20;121(4):579-91
• All: 3 reference(s)