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Runx1tm3(Runx3)Toku
Targeted Allele Detail
Summary
Symbol: Runx1tm3(Runx3)Toku
Name: runt related transcription factor 1; targeted mutation 3, Tsukasa Okuda
MGI ID: MGI:3581528
Synonyms: AML1-3
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm3(Runx3)Toku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98965
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailscDNA encoding the C-terminal region of Runx3, the polyA signal and a puromycin resistance cassette were inserted to replace the endogenous C-terminus. RT-PCR demonstrated mRNA levels were comparable to wild-type. (J:98965)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  34 strains or lines available
References
Original:  J:98965 Fukushima-Nakase Y, et al., Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood. 2005 Jun 1;105(11):4298-307
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory