Runx1^{tm4(Runx2)Toku}
Targeted Allele Detail

Summary

• Symbol: Runx1^{tm4(Runx2)Toku}
• Name: runt related transcription factor 1; targeted mutation 4, Tsukasa Okuda
• MGI ID: MGI:3581529
• Synonyms: AML1-2
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^{tm4(Runx2)Toku} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98965
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: cDNA encoding the C-terminal region of Runx2, the polyA signal and a puromycin resistance cassette were inserted to replace the endogenous C-terminus. RT-PCR demonstrated mRNA levels were comparable to wild-type. (J:98965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:98965 Fukushima-Nakase Y, et al., Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood. 2005 Jun 1;105(11):4298-307
• All: 1 reference(s)