Slamf6^tm1Dhow
Targeted Allele Detail

Summary

• Symbol: Slamf6^tm1Dhow
• Name: SLAM family member 6; targeted mutation 1, Duncan Howie
• MGI ID: MGI:3581614
• Synonyms: Ly108^deltaE2+3
• Gene: Slamf6 Location: Chr1:171745002-171776525 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Slamf6^tm1Dhow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the second and third exons, which encode the complete ectodomain. RT-PCR of mutant thymus failed to detect transcript corresponding to exons 2 and 3. (J:98995)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf6 Mutation: 33 strains or lines available

References

• Original: J:98995 Howie D, et al., Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol. 2005 May 15;174(10):5931-5
• All: 5 reference(s)