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Slamf6tm1Dhow
Targeted Allele Detail
Summary
Symbol: Slamf6tm1Dhow
Name: SLAM family member 6; targeted mutation 1, Duncan Howie
MGI ID: MGI:3581614
Synonyms: Ly108deltaE2+3
Gene: Slamf6  Location: Chr1:171745002-171776525 bp, + strand  Genetic Position: Chr1, 79.54 cM
Alliance: Slamf6tm1Dhow page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:98995
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the second and third exons, which encode the complete ectodomain. RT-PCR of mutant thymus failed to detect transcript corresponding to exons 2 and 3. (J:98995)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slamf6 Mutation:  33 strains or lines available
References
Original:  J:98995 Howie D, et al., Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol. 2005 May 15;174(10):5931-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory