Cd180^tm1Kmiy
Targeted Allele Detail

Summary

• Symbol: Cd180^tm1Kmiy
• Name: CD180 antigen; targeted mutation 1, Kensuke Miyake
• MGI ID: MGI:3581654
• Synonyms: RP105^-
• Gene: Cd180 Location: Chr13:102830055-102843139 bp, + strand Genetic Position: Chr13, 54.92 cM
• Alliance: Cd180^tm1Kmiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63145
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence in exon 3 encoding most of the extracellular LRR domain, the transmembrane and cytoplasmic domains was replaced with a PGK-neomycin resistance cassette. Flow cytometry failed to detect protein on mutant B cell surfaces. (J:63145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Cd180 Mutation: 52 strains or lines available

References

• Original: J:63145 Ogata H, et al., The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med. 2000 Jul 3;192(1):23-9
• All: 16 reference(s)