Tlx1^tm1Thr
Targeted Allele Detail

Summary

• Symbol: Tlx1^tm1Thr
• Name: T cell leukemia, homeobox 1; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:3581680
• Synonyms: Hox11^-, Hox11^tm1Rab, Tlx-
• Gene: Tlx1 Location: Chr19:45139119-45145382 bp, + strand Genetic Position: Chr19, 38.45 cM
• Alliance: Tlx1^tm1Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28700
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ-neo was inserted into exon 1 at codon 50, thereby preventing transcription of codons 51-189 and creating a null allele. (J:28700)

Expression

In Mice Carrying this Mutation:	123 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tlx1 Mutation: 20 strains or lines available

Notes

ES cell line = E14 (129P2/OlaHsd) or HM1 (129P2/OlaHsd-Hprt^b-m3).

References

• Original: J:28700 Dear TN, et al., The Hox11 gene is essential for cell survival during spleen development. Development. 1995 Sep;121(9):2909-15
• All: 9 reference(s)