Chrm4^tm1Minm
Targeted Allele Detail

Summary

• Symbol: Chrm4^tm1Minm
• Name: cholinergic receptor, muscarinic 4; targeted mutation 1, Minoru Matsui
• MGI ID: MGI:3581713
• Gene: Chrm4 Location: Chr2:91757594-91759033 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Chrm4^tm1Minm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99248
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo-bpA cassette in the reverse orientation replaced the coding region via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the brain. (J:99248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm4 Mutation: 35 strains or lines available

References

• Original: J:99248 Karasawa H, et al., Loss of anti-cataleptic effect of scopolamine in mice lacking muscarinic acetylcholine receptor subtype 4. Eur J Pharmacol. 2003 May 2;468(1):15-9
• All: 6 reference(s)