Chrm2^tm1Minm
Targeted Allele Detail

Summary

• Symbol: Chrm2^tm1Minm
• Name: cholinergic receptor, muscarinic 2, cardiac; targeted mutation 1, Minoru Matsui
• MGI ID: MGI:3581741
• Synonyms: M2^-
• Gene: Chrm2 Location: Chr6:36365019-36505349 bp, + strand Genetic Position: Chr6, 15.48 cM
• Alliance: Chrm2^tm1Minm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99247
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo-bpA cassette replaced the coding region via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the brain. (J:99247)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm2 Mutation: 33 strains or lines available

References

• Original: J:99247 Matsui M, et al., Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci. 2002 Dec 15;22(24):10627-32
• All: 8 reference(s)