Cma1^tm1Mfg
Targeted Allele Detail

Summary

• Symbol: Cma1^tm1Mfg
• Name: chymase 1, mast cell; targeted mutation 1, Michael F Gurish
• MGI ID: MGI:3581753
• Synonyms: Mcpt5^-
• Gene: Cma1 Location: Chr14:56178908-56182132 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Cma1^tm1Mfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene was inserted to the locus.

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Cma1^tm1Mfg/Cma1^tm1Mfg	either: (involves: 129 * C57BL/6) or (involves: 129 * BALB/c)

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
abnormal mast cell physiology	√
immune system	√
abnormal mast cell physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cma1 Mutation: 26 strains or lines available

References

• Original: J:98963 Abonia JP, et al., Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 1;174(11):7285-91
• All: 4 reference(s)