Tek^tm1Ber
Targeted Allele Detail

Summary

• Symbol: Tek^tm1Ber
• Name: TEK receptor tyrosine kinase; targeted mutation 1, Alan Bernstein
• MGI ID: MGI:3581758
• Synonyms: Tie2^F1100
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^tm1Ber page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99096
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to change tyrosine 1100 to phenylalanine (Y1100F). Flow cytometry of E9.5 embryos demonstrated expression of surface protein was comparable to that in wild-type embryos. (J:99096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 92 strains or lines available

References

• Original: J:99096 Tachibana K, et al., Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Mol Cell Biol. 2005 Jun;25(11):4693-702
• All: 1 reference(s)