Abca5^tm1Akya
Targeted Allele Detail

Summary

• Symbol: Abca5^tm1Akya
• Name: ATP-binding cassette, sub-family A member 5; targeted mutation 1, Akihito Yamaguchi
• MGI ID: MGI:3581814
• Synonyms: Abca5^-
• Gene: Abca5 Location: Chr11:110160195-110228542 bp, - strand Genetic Position: Chr11, 73.53 cM
• Alliance: Abca5^tm1Akya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99152
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neo cassette disrupted the region encoding the Walker A motif of NBD2, exon 31 and parts of exons 30 and 32. (J:99152)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abca5 Mutation: 84 strains or lines available

References

• Original: J:99152 Kubo Y, et al., ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. (Correction: v.25(13):5786). Mol Cell Biol. 2005 May;25(10):4138-49
• All: 2 reference(s)