Tg(GFAP)10Mes
Transgene Detail

Summary

• Symbol: Tg(GFAP)10Mes
• Name: transgene insertion 10, Albee Messing
• MGI ID: MGI:3581819
• Synonyms: GFAP^Tg, TgN(GFAP)Mes10
• Transgene: Tg(GFAP)10Mes Location: unknown
• Alliance: Tg(GFAP)10Mes page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP)10Mes expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: This transgene consists of a 17.5 kb fragment of DNA extending about 6 kb upstream to 1.5 kb downstream of the human GFAP gene, including regulatory elements sufficient to direct astrocyte-specific expression. Five lines were established 2 of which had high levels of expression in at least some mice (73.1 uniformly high expression and 73.7 about 20% with high expression). Line 73.7 was given a strain designation TgN(GFAP)Mes10. This is the representative record for both high expressing lines. (J:99256)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99256 Messing A, et al., Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Am J Pathol. 1998 Feb;152(2):391-8
• All: 9 reference(s)