Tg(GFAP)7Mes
Transgene Detail

Summary

• Symbol: Tg(GFAP)7Mes
• Name: transgene insertion 7, Albee Messing
• MGI ID: MGI:3581820
• Synonyms: Tg73.7
• Transgene: Tg(GFAP)7Mes Location: unknown
• Alliance: Tg(GFAP)7Mes page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(GFAP)7Mes expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: This transgene consists of a 17.5 kb fragment of DNA extending about 6 kb upstream to 1.5 kb downstream of the human GFAP gene, including regulatory elements sufficient to direct astrocyte-specific expression. Five lines were established 3 of which had low levels of expression, lines 72.2, 73.3 and 73.4 given the strain designations TgN(GFAP)Mes7, TgN(GFAP)Mes8, and TgN(GFAP)Mes9, respectively. This is the representative record for the low expressing lines. (J:99256)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:99256 Messing A, et al., Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Am J Pathol. 1998 Feb;152(2):391-8
• All: 5 reference(s)