Cd207^{tm3.1(HBEGF/EGFP)Mal}
Targeted Allele Detail

Summary

• Symbol: Cd207^{tm3.1(HBEGF/EGFP)Mal}
• Name: CD207 antigen; targeted mutation 3.1, Bernard Malissen
• MGI ID: MGI:3581827
• Synonyms: Cd207^{tm3(DTR/GFP)Mal}, Cd207^tm3Mal, Lang-DTR, Lang-DTREGFP
• Gene: Cd207 Location: Chr6:83648197-83654839 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
• Alliance: Cd207^{tm3.1(HBEGF/EGFP)Mal} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99114
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Cd207^{tm3.1(HBEGF/EGFP)Mal} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The following sequences were inserted in the 3' UTR: an IRES, the human diphtheria toxin receptor (HBEGF) cDNA coding region in-frame with the EGFP gene coding region, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site. Cre-mediated self-excision removed the cre+neo cassette in the male germline. (J:99114)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd207 Mutation: 25 strains or lines available

References

• Original: J:99114 Kissenpfennig A, et al., Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity. 2005 May;22(5):643-54
• All: 60 reference(s)