Klf7^tm1Rmz
Targeted Allele Detail

Summary

• Symbol: Klf7^tm1Rmz
• Name: Kruppel-like transcription factor 7 (ubiquitous); targeted mutation 1, Francesco Ramirez
• MGI ID: MGI:3581890
• Synonyms: DeltaK7-neo, Klf7^-
• Gene: Klf7 Location: Chr1:64068606-64161441 bp, - strand Genetic Position: Chr1, 32.31 cM, cytoband C1-C3
• Alliance: Klf7^tm1Rmz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo cassette replaced part of the 5'UTR and all of exon 1 by homologous recombination. In situ hybridization of mutant E13.5 spinal cord and P1 brain confirmed absence of transcript. Northern blot, RT-PCR and 5' RACE analyses further confirmed absence of transcript. (J:99181)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klf7 Mutation: 21 strains or lines available

References

• Original: J:99181 Laub F, et al., Transcription Factor KLF7 Is Important for Neuronal Morphogenesis in Selected Regions of the Nervous System. Mol Cell Biol. 2005 Jul;25(13):5699-711
• All: 8 reference(s)