Spint1^tm1Hk
Targeted Allele Detail

Summary

• Symbol: Spint1^tm1Hk
• Name: serine protease inhibitor, Kunitz type 1; targeted mutation 1, Hiroaki Kataoka
• MGI ID: MGI:3581891
• Synonyms: HAI-1^-
• Gene: Spint1 Location: Chr2:119067841-119079995 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E5
• Alliance: Spint1^tm1Hk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99182
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 5-11, which correspond to the first Kunitz domain, the LDL receptor class A domain, the second Kunitz domain, the transmembrane domain and the intracytoplasmic domain. RT-PCR of mutant embryos confirmed absence of transcript. (J:99182)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spint1 Mutation: 26 strains or lines available

References

• Original: J:99182 Tanaka H, et al., Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) Is Required for Branching Morphogenesis in the Chorioallantoic Placenta. Mol Cell Biol. 2005 Jul;25(13):5687-98
• All: 3 reference(s)