Mafa^tm1Staka
Targeted Allele Detail

Summary

• Symbol: Mafa^tm1Staka
• Name: MAF bZIP transcription factor A; targeted mutation 1, Satoru Takahashi
• MGI ID: MGI:3581892
• Synonyms: MafA^-
• Gene: Mafa Location: Chr15:75617339-75620077 bp, - strand Genetic Position: Chr15, 34.82 cM
• Alliance: Mafa^tm1Staka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99126
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An NLS-lacZ-neo cassette replaced sequences encoding both the transactivation and basic motif-leucine zipper domains. Beta-galactosidase expression was observed in the lens, somites and olfactory bulb, as well as pancreateic islets. (J:99126)

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mafa Mutation: 20 strains or lines available

References

• Original: J:99126 Zhang C, et al., MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol. 2005 Jun;25(12):4969-76
• All: 11 reference(s)