Thbs3^tm1Bst
Targeted Allele Detail

Summary

• Symbol: Thbs3^tm1Bst
• Name: thrombospondin 3; targeted mutation 1, Paul Bornstein
• MGI ID: MGI:3581964
• Synonyms: Thbs3^-
• Gene: Thbs3 Location: Chr3:89122487-89134144 bp, + strand Genetic Position: Chr3, 39.01 cM, cytoband E3-F1
• Alliance: Thbs3^tm1Bst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99120
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo flanked by loxP sites was inserted into exon B, incorporating an in-frame stop codon upstream from the cassette. Northern blot of RNA from mutant lungs confirmed creation of a null allele.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbs3 Mutation: 50 strains or lines available

References

• Original: J:99120 Hankenson KD, et al., Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol. 2005 Jul;25(13):5599-606
• All: 3 reference(s)