Oas1d^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Oas1d^tm1Zuk
• Name: 2'-5' oligoadenylate synthetase 1D; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:3581976
• Synonyms: Oas1d^-
• Gene: Oas1d Location: Chr5:121052881-121059711 bp, + strand Genetic Position: Chr5, 60.87 cM, cytoband F
• Alliance: Oas1d^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99134
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1 and part of exon 2, sequence encompassing the transcription start site, translation start site and 157 codons, with a PGK-hprt cassette. Immunohistochemsitry and Western blot analyses confirmed absence of protein in mutant ovaries. (J:99134)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oas1d Mutation: 26 strains or lines available

References

• Original: J:99134 Yan W, et al., Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005 Jun;25(11):4615-24
• All: 1 reference(s)