Ocln^tm1Sts
Targeted Allele Detail

Summary

• Symbol: Ocln^tm1Sts
• Name: occludin; targeted mutation 1, Shoichiro Tsukita
• MGI ID: MGI:3582233
• Gene: Ocln Location: Chr13:100633015-100689226 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Ocln^tm1Sts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99467
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, encoding the amino-terminal half of the first transmembrane to the second extracellular loop, was replaced by a lacZ-loxP-neo-loxP cassette. RT-PCR and western blot analysis confirmed the absence of mRNA and protein. (J:47807)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ocln Mutation: 33 strains or lines available

References

• Original: J:99467 Saitou M, et al., Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell. 2000 Dec;11(12):4131-42
• All: 11 reference(s)