Tspy-ps^{tm1(Mlc3-Gdf8)Mgs}
Targeted Allele Detail

Summary

• Symbol: Tspy-ps^{tm1(Mlc3-Gdf8)Mgs}
• Name: testis specific protein-Y encoded, pseudogene; targeted mutation 1, Michel Georges
• MGI ID: MGI:3582264
• Synonyms: TSPY-LAP
• Gene: Tspy-ps Location: ChrY:1056533-1058804 bp, - strand Genetic Position: ChrY, cytoband p
• Alliance: Tspy-ps^{tm1(Mlc3-Gdf8)Mgs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98460
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, RMCE-ready)
• Mutation: Insertion
• Mutation details: In a two-step process using insertional gene targeting and recombinase-mediated cassette exchange, a targeting vector containing Gdf8 under the control of the rat myosin light chain 1F promoter and enhancer, as well as an SV40 small tumor antigen intron and polyA signal was inserted into the locus. This vector was targeted using homology arms corresponding to nt 50690-57331. (J:98460)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspy-ps Mutation: 1 strain or line available

References

• Original: J:98460 Pirottin D, et al., Transgenic engineering of male-specific muscular hypertrophy. Proc Natl Acad Sci U S A. 2005 May 3;102(18):6413-8
• All: 1 reference(s)