Fgl2^tm1Pam
Targeted Allele Detail

Summary

• Symbol: Fgl2^tm1Pam
• Name: fibrinogen-like protein 2; targeted mutation 1, Philip A Marsden
• MGI ID: MGI:3582343
• Synonyms: Fgl2^-
• Gene: Fgl2 Location: Chr5:21577671-21583384 bp, + strand Genetic Position: Chr5, 9.83 cM
• Alliance: Fgl2^tm1Pam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ-neo cassette replaced the first two codons of exon 1. RT-PCR confirmed absence of transcript in mutant macrophages. (J:99453)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgl2 Mutation: 27 strains or lines available

References

• Original: J:99453 Marsden PA, et al., The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. J Clin Invest. 2003 Jul;112(1):58-66
• All: 18 reference(s)