Tg(BCR/ABL)623Hkp
Transgene Detail

Summary

• Symbol: Tg(BCR/ABL)623Hkp
• Name: transgene insertion 623, Nora Heisterkamp
• MGI ID: MGI:3582388
• Synonyms: BCR-ABL1, P190 BCR-ABL, P190 BCR/ABL
• Transgene: Tg(BCR/ABL)623Hkp Location: unknown
• Alliance: Tg(BCR/ABL)623Hkp page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCR/ABL)623Hkp expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ABL1 (25)

  Abl1	(MGI:87859)

  human

  BCR (613)

  Bcr	(MGI:88141)

• Mutation details: The mouse metallothionein-1 promoter drives expression of the human p190 BCR/ABL fusion gene that has the ABL oncogene fused head to tail with the 5' exons of the BCR gene with the break occurring in the first intron. This fusion gene produces the p190 protein with abnormal tyrosin kinase activity. Founder 623 was used to generate the transgenic line. (J:91174)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(BCR/ABL)623Hkp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:89786 Voncken JW, et al., Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res. 1992 Aug 15;52(16):4534-9
• All: 21 reference(s)