Pou4f2^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Pou4f2^tm1Rsd
• Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:3582493
• Synonyms: Brn3.2^-
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33502
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A neomycin selection cassette replaced a 2.7 kb genomic fragment containing the entire coding sequence of the gene. Immunohistochemical analysis on sections of newborn dorsal root ganglia of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:33502)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
• All: 2 reference(s)