Tnfrsf14^tm1Kpf
Targeted Allele Detail

Summary

• Symbol: Tnfrsf14^tm1Kpf
• Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:3582550
• Synonyms: HVEM^-
• Gene: Tnfrsf14 Location: Chr4:155006390-155013020 bp, - strand Genetic Position: Chr4, 85.81 cM
• Alliance: Tnfrsf14^tm1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99456
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2, 3, and the 5' region of exon 4 were replaced by an intron gene trap cassette encompassing an engrailed-2 splice acceptor sequence, a beta-gal cassette, and a neomycin gene resistance cassette. Northern blot analysis of RNA from splenic tissues confirmed the null mutation. (J:99456)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf14 Mutation: 20 strains or lines available

References

• Original: J:99456 Wang Y, et al., The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest. 2005 Mar;115(3):711-7
• All: 29 reference(s)