Ighm^tm1Sls
Targeted Allele Detail

Summary

• Symbol: Ighm^tm1Sls
• Name: immunoglobulin heavy constant mu; targeted mutation 1, Erik Selsing
• MGI ID: MGI:3582575
• Synonyms: Smu
• Gene: Ighm Location: Chr12:113382446-113386350 bp, - strand Genetic Position: Chr12, 62.1 cM, cytoband F1-2
• Alliance: Ighm^tm1Sls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99465
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire tandem repeat region was replaced by a Neo/loxP cassette which was later removed by crossing to a Cre recombinase transgenic strain, leaving one loxP site. The enhancer, matrix attachment regions and the I exon were left intact. (J:99465)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighm Mutation: 56 strains or lines available

References

• Original: J:99465 Luby TM, et al., The mu switch region tandem repeats are important, but not required, for antibody class switch recombination. J Exp Med. 2001 Jan 15;193(2):159-68
• All: 6 reference(s)