Itgal^tm1Hlz
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1Hlz
• Name: integrin alpha L; targeted mutation 1, Bernhard Holzmann
• MGI ID: MGI:3582587
• Synonyms: Lfa-1^d
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1Hlz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99286
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A constitutive germline deletion of the amino acid motif GFFKR in the membrane proximal segment of the cytoplasmic domain, was accomplished by insertion of a neomycin resistance cassette and a HSV-thymidine kinase cassette. The neo was later removed by crossing to a cre expressing strain. (J:99286)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 76 strains or lines available

References

• Original: J:99286 Semmrich M, et al., Importance of integrin LFA-1 deactivation for the generation of immune responses. J Exp Med. 2005 Jun 20;201(12):1987-98
• All: 3 reference(s)