Cyp11b2^tm1Hsk
Targeted Allele Detail

Summary

• Symbol: Cyp11b2^tm1Hsk
• Name: cytochrome P450, family 11, subfamily b, polypeptide 2; targeted mutation 1, Hyung-Suk Kim
• MGI ID: MGI:3582593
• Synonyms: AS^-, Cyp11b2^tm1Unc
• Gene: Cyp11b2 Location: Chr15:74722859-74728167 bp, - strand Genetic Position: Chr15, 34.29 cM
• Alliance: Cyp11b2^tm1Hsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99269
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP-neo cassette replaced exons 1 and 2 and the 5' part of exon 3. Transcript was undetected in RT-PCR analysis of mutant adrenal gland samples. (J:99269)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp11b2 Mutation: 41 strains or lines available

References

• Original: J:99269 Lee G, et al., Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology. 2005 Jun;146(6):2650-6
• All: 16 reference(s)