Bdnf^tm1Krj
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Krj
• Name: brain derived neurotrophic factor; targeted mutation 1, Kevin R Jones
• MGI ID: MGI:3582638
• Synonyms: Bdnf^klox, BDNF^lox, BDNF-loxp, BDNF-LSL-LacZ
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Krj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84683
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to flank the pro encoding region and mature hormone-encoding region of exon V with loxP sites, with a trimerized polyadenylation signal upstream of the 3' loxP sequence and a lacZ gene and FRT-flanked neomycin resistance cassette downstream of the 3' loxP sequence. Cre mediated excision would enable transcription and translation of lacZ in place of Bdnf. (J:84683)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:84683 Gorski JA, et al., Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci. 2003 Jul 30;23(17):6856-65
• All: 31 reference(s)