Hcn2^trls
Spontaneous Allele Detail

Summary

• Symbol: Hcn2^trls
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; tremor and reduced lifespan
• MGI ID: MGI:3582957
• Gene: Hcn2 Location: Chr10:79552468-79571942 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Hcn2^trls page

Mutation origin

• Strain of Origin: BKS.Cg-Dock7^m +/+ Lepr^db/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This spontaneous mutation has a G-to-A transition at chromosome 10 position 79,724,780 (GRCm38) that causes an arginine to glutamine substitution at residue 315 (p.R315Q). (J:187506, J:222308)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcn2 Mutation: 31 strains or lines available

References

• Original: J:103185 Samples R, et al., Tremor and reduced lifespan (trls): a new neurological mutation on Chromosome 10. MGI Direct Data Submission. 2005
• All: 4 reference(s)