Gabrg2^tm2.1Geh
Targeted Allele Detail

Summary

• Symbol: Gabrg2^tm2.1Geh
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 2; targeted mutation 2.1, Gregg E Homanics
• MGI ID: MGI:3582967
• Gene: Gabrg2 Location: Chr11:41801030-41891684 bp, - strand Genetic Position: Chr11, 24.8 cM
• Alliance: Gabrg2^tm2.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98560
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed exon 8 was deleted from Gabrg2^tm2Geh mice by cre-mediated recombination using Tg(ACTB-cre)2Mrt mice. (J:98560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabrg2 Mutation: 41 strains or lines available

References

• Original: J:98560 Chandra D, et al., GABAA receptor gamma2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci. 2005 Apr 25;6(1):30
• All: 2 reference(s)