Fcer2a^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Fcer2a^tm1Kik
• Name: Fc receptor, IgE, low affinity II, alpha polypeptide; targeted mutation 1, Hitoshi Kikutani
• MGI ID: MGI:3583003
• Synonyms: CD23^-
• Gene: Fcer2a Location: Chr8:3731737-3744175 bp, - strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Fcer2a^tm1Kik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19437
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 4. Northern blot of mutant lymphocytes confirmed absence of transcript. (J:19437)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fcer2a Mutation: 24 strains or lines available

References

• Original: J:19437 Fujiwara H, et al., The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6835-9
• All: 14 reference(s)