Tg(Ins2-OVA)59Wehi
Transgene Detail

Summary

• Symbol: Tg(Ins2-OVA)59Wehi
• Name: transgene insertion 59, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:3583258
• Synonyms: RIP-OVA^hi, RIP-sOVA
• Transgene: Tg(Ins2-OVA)59Wehi Location: unknown
• Alliance: Tg(Ins2-OVA)59Wehi page

Transgene origin

• Strain of Origin: B6.C-H2^bm1/ByJWehi

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-OVA)59Wehi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	OVAL (396058)

• Mutation details: Mice bearing this transgene express a secreted form of ovalbumin from the full-length chicken ovalbumin cDNA under control of the rat insulin 2 promoter. (J:99451)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The pancreatic islets of transgenic mice exhibit weak ovalbumin- (OV-) specific immunohistologic staining. Western blot analysis measures the islet OV content as 1.0 +/- 0.4 ng/'ug of protein. These mice develop diabetes following adoptive transfer of activated, but not naive, CD8+ T lymphocytes from mice bearing Tg(TcraTcrb)1100Mjb (OT-1).

References

• Original: J:99560 Kurts C, et al., Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction. J Exp Med. 1998 Jul 20;188(2):409-14
• All: 25 reference(s)