Vezf1^tm1Stmn
Targeted Allele Detail

Summary

• Symbol: Vezf1^tm1Stmn
• Name: vascular endothelial zinc finger 1; targeted mutation 1, Heidi Stuhlmann
• MGI ID: MGI:3583268
• Synonyms: Vezf1^-
• Gene: Vezf1 Location: Chr11:87959105-87975555 bp, + strand Genetic Position: Chr11, 52.4 cM
• Alliance: Vezf1^tm1Stmn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99326
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector replaced exon 1 and the proximal part of the first intron with a promoter-less IRES-lacZgt1.2neo cassette. The deletion included 91 bp upstream of the transcriptional start site, resulting in a null allele. Protein expression was reduced in heterozygous and undetectable in homozygous mutant embryos. (J:99326)

Expression

In Mice Carrying this Mutation:	56 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vezf1 Mutation: 27 strains or lines available

References

• Original: J:99326 Kuhnert F, et al., Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
• All: 4 reference(s)