Hus1^tm1Rsw
Targeted Allele Detail

Summary

• Symbol: Hus1^tm1Rsw
• Name: HUS1 checkpoint clamp component; targeted mutation 1, Robert S Weiss
• MGI ID: MGI:3583575
• Synonyms: Hus1^flox
• Gene: Hus1 Location: Chr11:8943137-8961191 bp, - strand Genetic Position: Chr11, 5.74 cM
• Alliance: Hus1^tm1Rsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99339
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is a child of Hus1^tm2Rsw, and resulted from crossing those with mice expressing FLP recombinase in the germline to remove the FRT flanked neomycin resistance cassette. Exons 2 and 3 remained flanked by loxP sites. (J:99339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hus1 Mutation: 20 strains or lines available

References

• Original: J:99339 Levitt PS, et al., Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics. 2005 Aug;86(2):212-24
• All: 5 reference(s)