Hus1^tm1.1Rsw
Targeted Allele Detail

Summary

• Symbol: Hus1^tm1.1Rsw
• Name: HUS1 checkpoint clamp component; targeted mutation 1.1, Robert S Weiss
• MGI ID: MGI:3583576
• Synonyms: Hus1^delta2,3
• Gene: Hus1 Location: Chr11:8943137-8961191 bp, - strand Genetic Position: Chr11, 5.74 cM
• Alliance: Hus1^tm1.1Rsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99339
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Hus1^tm1Rsw mice were crossed with mice expressing cre in the germline, resulting in the excision of exons 2 and 3. Sequencing of RT-PCR products from mutants confirmed the lack of exons 2 and 3 as well as the first three nucleotides of exon 4. (J:99339)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hus1 Mutation: 20 strains or lines available

References

• Original: J:99339 Levitt PS, et al., Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics. 2005 Aug;86(2):212-24
• All: 2 reference(s)