Ddit4^tm1Lwe
Targeted Allele Detail

Summary

• Symbol: Ddit4^tm1Lwe
• Name: DNA-damage-inducible transcript 4; targeted mutation 1, Leif W Ellisen
• MGI ID: MGI:3583650
• Synonyms: REDD1^-
• Gene: Ddit4 Location: Chr10:59785497-59787592 bp, - strand Genetic Position: Chr10, 29.66 cM, cytoband B3
• Alliance: Ddit4^tm1Lwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99368
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region and the 3' UTR were replaced with a betagalactosidase-neomycin fusion protein. Northern blot and Western blot of mutant MEFs confirmed absence of transcript and protein, respectively. (J:99368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddit4 Mutation: 18 strains or lines available

References

• Original: J:99368 Sofer A, et al., Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1. Mol Cell Biol. 2005 Jul;25(14):5834-45
• All: 6 reference(s)