Cpa3^tm1Hrr
Targeted Allele Detail

Summary

• Symbol: Cpa3^tm1Hrr
• Name: carboxypeptidase A3, mast cell; targeted mutation 1, Hans-Reimer Rodewald
• MGI ID: MGI:3583651
• Synonyms: Mc-cpa^-
• Gene: Cpa3 Location: Chr3:20269784-20296345 bp, - strand Genetic Position: Chr3, 6.25 cM
• Alliance: Cpa3^tm1Hrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99367
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert an EGFP upstream of exon 1. Western blot of mutant mast cells confirmed absence of protein. (J:99367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpa3 Mutation: 30 strains or lines available

References

• Original: J:99367 Feyerabend TB, et al., Loss of histochemical identity in mast cells lacking carboxypeptidase a. Mol Cell Biol. 2005 Jul;25(14):6199-210
• All: 7 reference(s)