Sin3a^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Sin3a^tm1Rdp
• Name: transcriptional regulator, SIN3A (yeast); targeted mutation 1, Ronald DePinho
• MGI ID: MGI:3583655
• Synonyms: mSin3A^L, Sin3a^Flox
• Gene: Sin3a Location: Chr9:56979324-57035650 bp, + strand Genetic Position: Chr9, 30.89 cM
• Alliance: Sin3a^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exon 4. (J:99406)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sin3a Mutation: 62 strains or lines available

Notes

Homozygous MEFs infected with viral cre stop proliferating, display increased apoptosis, and show G2/M and S phase cell cycle arrest; however, no increase in chromosomal instability is seen. Similar results are seen when MEFs are infected with a tamoxifen inducible cre/estrogen receptor construct. (J:99406)

References

• Original: J:99406 Dannenberg JH, et al., mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 2005 Jul 1;19(13):1581-95
• All: 14 reference(s)