Tg(Mef2c-cre)1Blk
Transgene Detail
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Symbol: |
Tg(Mef2c-cre)1Blk |
Name: |
transgene insertion 1, Brian L Black |
MGI ID: |
MGI:3583679 |
Synonyms: |
line 441G, mef2c-73k-Cre, Mef2cCre |
Transgene: |
Tg(Mef2c-cre)1Blk Location: unknown
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Alliance: |
Tg(Mef2c-cre)1Blk page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Mef2c-cre)1Blk expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
Not Specified |
Mef2c |
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Mutation details: Cre recombinase is under the control of a 954-bp highly conserved promoter active in all skeletal muscles. Five of eight founder lines induced recombination when crossed to R26R reporter mice. 3 lines (44K, 441G and 453G) showed robust cre activity at E11.5 in skeletal muscle exclusively. The line created here represents line 441G.
(J:99340)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Mef2c
(species not specified)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6NTac | |
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Phenotypes: |
Affected Systems |
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mortality/aging
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postnatal lethality, complete penetrance
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√
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muscle
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√
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abnormal Z line morphology
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√
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abnormal skeletal muscle morphology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:99340 Heidt AB, et al., Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis. 2005 May;42(1):28-32 |
All: |
9 reference(s) |
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