Tg(Mef2c-cre)1Blk
Transgene Detail

Summary

• Symbol: Tg(Mef2c-cre)1Blk
• Name: transgene insertion 1, Brian L Black
• MGI ID: MGI:3583679
• Synonyms: line 441G, mef2c-73k-Cre, Mef2c^Cre
• Transgene: Tg(Mef2c-cre)1Blk Location: unknown
• Alliance: Tg(Mef2c-cre)1Blk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Mef2c-cre)1Blk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Mef2c

• Mutation details: Cre recombinase is under the control of a 954-bp highly conserved promoter active in all skeletal muscles. Five of eight founder lines induced recombination when crossed to R26R reporter mice. 3 lines (44K, 441G and 453G) showed robust cre activity at E11.5 in skeletal muscle exclusively. The line created here represents line 441G. (J:99340)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mef2c (species not specified) Summary of all recombinase alleles driven by Mef2c. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Cfl2^tm1Itl/Cfl2^tm1Itl Tg(Mef2c-cre)1Blk/0	involves: C57BL/6NTac

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
mortality/aging	√
postnatal lethality, complete penetrance	√
muscle	√
abnormal Z line morphology	√
abnormal skeletal muscle morphology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:99340 Heidt AB, et al., Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis. 2005 May;42(1):28-32
• All: 9 reference(s)