Ms4a2^tm1Chr
Targeted Allele Detail

Summary

• Symbol: Ms4a2^tm1Chr
• Name: membrane-spanning 4-domains, subfamily A, member 2; targeted mutation 1, Chisei Ra
• MGI ID: MGI:3583705
• Synonyms: FcRB(-), FcRbeta(-)
• Gene: Ms4a2 Location: Chr19:11592887-11601083 bp, - strand Genetic Position: Chr19, 8.46 cM
• Alliance: Ms4a2^tm1Chr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53106
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1, which includes the translation initiation codon and splice donor site, via homologous recombination. Northern blot and western blot analyses failed to detect signal in homozygotes indicating a null allele. (J:53106)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a2 Mutation: 12 strains or lines available

References

• Original: J:53106 Hiraoka S, et al., Fc receptor beta subunit is required for full activation of mast cells through Fc receptor engagement. Int Immunol. 1999 Feb;11(2):199-207
• All: 7 reference(s)