Gsdme^tm1Ant
Targeted Allele Detail

Summary

• Symbol: Gsdme^tm1Ant
• Name: gasdermin E; targeted mutation 1, University of Antwerp
• MGI ID: MGI:3583715
• Gene: Gsdme Location: Chr6:50167013-50240837 bp, - strand Genetic Position: Chr6, 24.13 cM
• Alliance: Gsdme^tm1Ant page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99624
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A hygromycin resistance cassette flanked by loxP sites replaced exon 8 via homologous recombination. An additional loxP site was inserted between exons 6 and 7. Without cre recombinase exposure this allele was found by RT-PCR to produce appropriately aberrant transcript and western blot analysis failed to detect the protein in homozygotes. (J:99624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdme Mutation: 42 strains or lines available

References

• Original: J:99624 Van Laer L, et al., Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells. Neurobiol Dis. 2005 Aug;19(3):386-99
• All: 2 reference(s)