Npr2^cn-3J
Spontaneous Allele Detail

Summary

• Symbol: Npr2^cn-3J
• Name: natriuretic peptide receptor 2; achondroplasia 3 Jackson
• MGI ID: MGI:3583746
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^cn-3J page

Disproportionate dwarf phenotype in Npr2^cn-3J/Npr2^cn-3J mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: MRL/MpJ-Fas^lpr/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: A failed complementation test of this spontaneous mutant with the Npr2^cn-2J allele demonstrated that this mutation is an allele of Npr2, and a G-to-A transition was identified in chromosome 4 position 43650227 (GRCm38), which is in exon 19 and causes an alanine to threonine substitution at position 931 (p.A931T). (J:170669)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:170669 Karst SY, et al., A remutation to achondroplasia in the MRL/MpJ inbred background: Npr2cn-3J. MGI Direct Data Submission. 2011
• All: 1 reference(s)