Xist^tm1Sado
Targeted Allele Detail

Summary

• Symbol: Xist^tm1Sado
• Name: inactive X specific transcripts; targeted mutation 1, Takashi Sado
• MGI ID: MGI:3583749
• Synonyms: Xist^1lox
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm1Sado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99399
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting construct was designed to replace part of exon 1 with an IRES-EGFP cassette such that the reporter is under the control of the endogenous promoter. The construct was inserted into mutated J1 ES cells lacking Tsix ("#6 cells"). (J:99399)

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:99399 Sado T, et al., Tsix Silences Xist through Modification of Chromatin Structure. Dev Cell. 2005 Jul;9(1):159-165
• All: 2 reference(s)