Rbpj^tm1Hon
Targeted Allele Detail

Summary

• Symbol: Rbpj^tm1Hon
• Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Tasuku Honjo
• MGI ID: MGI:3583755
• Synonyms: RBP^f, RBP-J^C, RBP-J^f, Rbpj^flox, Rbp-J^flox, RBP-Jkappa^Fl, RBP-Jkappa^flox, RBPJkappa^loxP, RBP-J^lox, Rbpj^loxP, Rbpsuh^tm3Kyo
• Gene: Rbpj Location: Chr5:53713121-53814787 bp, + strand Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
• Alliance: Rbpj^tm1Hon page

The number of melanocyte lineage cells is dramatically reduced in Rbpj^tm1Hon Rbpj^tm1Hon Tg(Tyr-cre)#Lru/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99747
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 6, which encodes the DNA binding domain, and exon 7. In addition, a neomycin resistance gene was inserted between exon 7 and the 3' loxP site. (J:99747)

Expression

In Mice Carrying this Mutation:	52390 assay results 16 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rbpj Mutation: 193 strains or lines available

References

• Original: J:99747 Han H, et al., Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 2002 Jun;14(6):637-45
• All: 346 reference(s)