Cxadr^tm1Rwf
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1Rwf
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Robert W Finberg
• MGI ID: MGI:3583765
• Synonyms: CARdelta2
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1Rwf page

Cxadr^tm1Rwf/Cxadr^tm1Rwf embryos hemorrhage at E11-11.5

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99585
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 2, which encodes part of the Ig-V-like domain. RT-PCR confirmed splicing of exon 1 directly to exon 3. (J:99585)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:99585 Asher DR, et al., Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis. 2005 Jun;42(2):77-85
• All: 1 reference(s)